Dr. Michael Weller has been Chairman of the Department of Neurology at the University Hospital Zurich, Switzerland, since 2008. He qualified in medicine in Cologne, Germany, after completing his thesis on proliferative disorders of the retina. A postdoctoral fellowship at the Department of Clinical Immunology, University Hospital Zurich, Switzerland, followed where he identified death receptor targeting as a potential treatment strategy for glioblastoma. In 2005, he was appointed Chairman of the Department of General Neurology at the University Hospital Tübingen, Germany, where he had previously received his education in clinical neurology.
Dr. Weller has received several awards in recognition of his contributions to cancer research, including the German Cancer Award in 2007. He served as Chairman of the Neuro-Oncology Group of the German Cancer Society from 2001-2008. He is the Chairman of the German Glioma Network of the German Cancer Council, joined the Executive Board of the European Association for Neuro-Oncology (EANO) in 2010 and served as President of EANO for 2014-2016. He was also the Chairman of the Brain Tumor Group of the European Organization for Research and Treatment of Cancer (EORTC) (2015-2021) and hosted the World Federation of Neuro-Oncology Societies (WFNOS) Meeting 2017 in Zurich, Switzerland.
He serves as a member of the editorial boards of the Journal of Clinical Oncology (2012-2014), Journal of Neurochemistry, Journal of Neuro-Oncology, Brain (2011-2020), Glia and Neuro-Oncology, and he was the Associate Editor Europe of Neuro-Oncology from 2006-2013.
Dr. Weller was involved in major practice-changing clinical trials including the registration trial for temozolomide in glioblastoma and served as Principle Investigator on the NOA-03, NOA-04, NOA-08 and G-PCNSL-SG-1 trials in Germany and the DIRECTOR and ARTE trials in Switzerland. Dr. Weller has a research focus on the immunology of gliomas and served as the Principle Investigator of the phase III immunotherapy trial, ACT IV (Rindopepimut). He was a lead investigator in the three immune checkpoint inhibitor trials in glioblastoma, CheckMate 143, 498 and 548. Furthermore, his team has established a close collaboration with the Zurich-based company Philogen to develop novel immunotherapeutic agents referred to as immunocytokines that are now tested in early clinical trials.
The Laboratory of Molecular Neuro-Oncology at the University Hospital and University of Zurich led by the applicant has a major research focus on the development of innovative treatment approaches to brain tumors, including immunocytokines and CAR T cells, and molecular pathways of constitutive and acquired resistence to current therapies.
Dr. Weller has co-authored more than 750 original publications in peer-reviewed journals, including The New England Journal of Medicine, Cell, Science, Nature, Nature Medicine, Lancet Oncology, PNAS, The Journal of Clinical Investigation, and The Journal of Clinical Oncology.